The recommended way to use the GnuPG crypto stack from your application is GPGME.

Python wrappers

• http://pyme.sourceforge.net/ SWIG generated wrapper
• https://launchpad.net/pygpgme manually written wrapper in C

C++ wrappers

• http://quickgit.kde.org/?p=kdepimlibs.git gpgme++ is a wrapper for gpgme in kdepimlibs