TODO (Feel Free to add information, please indicate if it is Free Software or not and if it uses the recommended GPGME and uiserver APIs of GnuPG)
Enigmail
a data encryption and decryption extension for Mozilla Thunderbird and the SeaMonkey internet suite that provides OpenPGP public key e-mail encryption and signing.
License: MPL 2, GNU GPL 2+
API: no GPGME, no UIServer
CipherMail Email Encryption Gateway
http://www.ciphermail.com/gateway.html
License GNU +APL 3 (some additional permissions)
Former DJIGZO provides a solution to securing your email without requiring additional client software. The centralized policy based encryption engine can be setup to automatically encrypt email based on regulatory compliance or business rules
API: no GPGME, no UIServer. Seems to call gpg directly.
gpg4usb
http://www.gpg4usb.org seems to use GnuPG 1.4.x and Qt.
portable-application, which combines a simple text-editor with a GnuPG-frontend to write, encrypt and decrypt your text-messages and files.
API: Version 0.3.3 may still use GPGME. The TODO file aims for the use of its own kgpg connection. no UIServer
duplicity
Duplicity backs directories by producing encrypted tar-format volumes and uploading them to a remote or local file server. [..] uses GnuPG to encrypt and/or sign these archives
License GNU GPL v>=2.
API: uses its own embedded gpginterface.py, process based, does not use GPGME